IL17A Back

interleukin 17A

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IL17A
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Community Annotation of IL17A Add / Edit IL17A: Annotations

No community annotations yet for IL17A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IL17A is highly significantly mutated in
(none)
IL17A is significantly mutated in
(none)
IL17A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IL17A