IL12RB1 Back

interleukin 12 receptor, beta 1

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NCBI Description of IL12RB1

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Community Annotation of IL12RB1 Add / Edit IL12RB1: Annotations

No community annotations yet for IL12RB1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IL12RB1 is highly significantly mutated in
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IL12RB1 is significantly mutated in
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IL12RB1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for IL12RB1