IL10RA Back

interleukin 10 receptor, alpha

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IL10RA
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Community Annotation of IL10RA Add / Edit IL10RA: Annotations

No community annotations yet for IL10RA.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IL10RA is highly significantly mutated in
(none)
IL10RA is significantly mutated in
(none)
IL10RA is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IL10RA