IKBKG Back

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

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NCBI Description of IKBKG
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IKBKG is highly significantly mutated in
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IKBKG is significantly mutated in
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IKBKG is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IKBKG