IKBKE Back

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

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NCBI Description of IKBKE

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IKBKE is highly significantly mutated in
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IKBKE is significantly mutated in
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IKBKE is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for IKBKE