IKBKAP Back

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IKBKAP
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.

Community Annotation of IKBKAP Add / Edit IKBKAP: Annotations

No community annotations yet for IKBKAP.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IKBKAP is highly significantly mutated in
(none)
IKBKAP is significantly mutated in
(none)
IKBKAP is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IKBKAP