IGSF8 Back

immunoglobulin superfamily, member 8

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NCBI Description of IGSF8
This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein.

Community Annotation of IGSF8 Add / Edit IGSF8: Annotations

No community annotations yet for IGSF8.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IGSF8 is highly significantly mutated in
(none)
IGSF8 is significantly mutated in
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IGSF8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IGSF8