IGFBP4 Back

insulin-like growth factor binding protein 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IGFBP4

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Community Annotation of IGFBP4 Add / Edit IGFBP4: Annotations

No community annotations yet for IGFBP4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IGFBP4 is highly significantly mutated in
(none)
IGFBP4 is significantly mutated in
(none)
IGFBP4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for IGFBP4