insulin-like growth factor binding protein 1

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NCBI Description of IGFBP1

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Community Annotation of IGFBP1 Add / Edit IGFBP1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IGFBP1 is highly significantly mutated in
IGFBP1 is significantly mutated in
IGFBP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IGFBP1