IGFALS Back

insulin-like growth factor binding protein, acid labile subunit

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NCBI Description of IGFALS
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of IGFALS Add / Edit IGFALS: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IGFALS is highly significantly mutated in
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IGFALS is significantly mutated in
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IGFALS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IGFALS