IGF2BP3 Back

insulin-like growth factor 2 mRNA binding protein 3

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NCBI Description of IGF2BP3

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IGF2BP3 is highly significantly mutated in
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IGF2BP3 is significantly mutated in
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IGF2BP3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for IGF2BP3