IGF2BP2 Back

insulin-like growth factor 2 mRNA binding protein 2

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NCBI Description of IGF2BP2

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IGF2BP2 is highly significantly mutated in
IGF2BP2 is significantly mutated in
IGF2BP2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IGF2BP2