IGF1R Back

insulin-like growth factor 1 receptor

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NCBI Description of IGF1R
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IGF1R is highly significantly mutated in
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IGF1R is significantly mutated in
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IGF1R is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IGF1R