IGF1 Back

insulin-like growth factor 1 (somatomedin C)

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NCBI Description of IGF1

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IGF1 is highly significantly mutated in
IGF1 is significantly mutated in
IGF1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IGF1