IFT140 Back

intraflagellar transport 140 homolog (Chlamydomonas)

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NCBI Description of IFT140
This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IFT140 is highly significantly mutated in
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IFT140 is significantly mutated in
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IFT140 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IFT140