IFNGR2 Back

interferon gamma receptor 2 (interferon gamma transducer 1)

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NCBI Description of IFNGR2
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.

Community Annotation of IFNGR2 Add / Edit IFNGR2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IFNGR2 is highly significantly mutated in
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IFNGR2 is significantly mutated in
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IFNGR2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IFNGR2