IER3IP1 Back

immediate early response 3 interacting protein 1

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NCBI Description of IER3IP1
This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IER3IP1 is highly significantly mutated in
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IER3IP1 is significantly mutated in
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IER3IP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IER3IP1