IDS Back

iduronate 2-sulfatase (Hunter syndrome)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of IDS
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.

Community Annotation of IDS Add / Edit IDS: Annotations

No community annotations yet for IDS.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

IDS is highly significantly mutated in
(none)
IDS is significantly mutated in
(none)
IDS is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for IDS