ICMT Back

isoprenylcysteine carboxyl methyltransferase

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NCBI Description of ICMT
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Community Annotation of ICMT Add / Edit ICMT: Annotations

No community annotations yet for ICMT.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ICMT is highly significantly mutated in
(none)
ICMT is significantly mutated in
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ICMT is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ICMT