ICAM3 Back

intercellular adhesion molecule 3

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NCBI Description of ICAM3

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.

Community Annotation of ICAM3 Add / Edit ICAM3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ICAM3 is highly significantly mutated in
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ICAM3 is significantly mutated in
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ICAM3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for ICAM3