inhibitor of Bruton agammaglobulinemia tyrosine kinase

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NCBI Description of IBTK

The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


IBTK is highly significantly mutated in
IBTK is significantly mutated in
IBTK is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for IBTK