HVCN1 Back

hydrogen voltage-gated channel 1

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NCBI Description of HVCN1

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HVCN1 is highly significantly mutated in
HVCN1 is significantly mutated in
HVCN1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HVCN1