HTR3D Back

5-hydroxytryptamine (serotonin) receptor 3 family member D

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HTR3D

The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of HTR3D Add / Edit HTR3D: Annotations

No community annotations yet for HTR3D.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HTR3D is highly significantly mutated in
HTR3D is significantly mutated in
HTR3D is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HTR3D