HTR3C Back

5-hydroxytryptamine (serotonin) receptor 3, family member C

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NCBI Description of HTR3C

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HTR3C is highly significantly mutated in
HTR3C is significantly mutated in
HTR3C is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HTR3C