HTR3A Back

5-hydroxytryptamine (serotonin) receptor 3A

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HTR3A
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of HTR3A Add / Edit HTR3A: Annotations

No community annotations yet for HTR3A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HTR3A is highly significantly mutated in
(none)
HTR3A is significantly mutated in
(none)
HTR3A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HTR3A