HTR1B Back

5-hydroxytryptamine (serotonin) receptor 1B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HTR1B

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009].

Community Annotation of HTR1B Add / Edit HTR1B: Annotations

No community annotations yet for HTR1B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HTR1B is highly significantly mutated in
HTR1B is significantly mutated in
HTR1B is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HTR1B