HTR1A Back

5-hydroxytryptamine (serotonin) receptor 1A

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HTR1A

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.

Community Annotation of HTR1A Add / Edit HTR1A: Annotations

No community annotations yet for HTR1A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HTR1A is highly significantly mutated in
HTR1A is significantly mutated in
HTR1A is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HTR1A