HSPE1 Back

heat shock 10kDa protein 1 (chaperonin 10)

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NCBI Description of HSPE1

This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HSPE1 is highly significantly mutated in
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HSPE1 is significantly mutated in
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HSPE1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for HSPE1