HSH2D Back

hematopoietic SH2 domain containing

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NCBI Description of HSH2D
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008].

Community Annotation of HSH2D Add / Edit HSH2D: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HSH2D is highly significantly mutated in
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HSH2D is significantly mutated in
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HSH2D is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HSH2D