HSF4 Back

heat shock transcription factor 4

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NCBI Description of HSF4
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.

Community Annotation of HSF4 Add / Edit HSF4: Annotations

No community annotations yet for HSF4.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HSF4 is highly significantly mutated in
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HSF4 is significantly mutated in
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HSF4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HSF4