HSD17B6 Back

hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)

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NCBI Description of HSD17B6
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HSD17B6 is highly significantly mutated in
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HSD17B6 is significantly mutated in
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HSD17B6 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HSD17B6