HSD17B3 Back

hydroxysteroid (17-beta) dehydrogenase 3

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NCBI Description of HSD17B3
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HSD17B3 is highly significantly mutated in
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HSD17B3 is significantly mutated in
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HSD17B3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HSD17B3