HS6ST2 Back

heparan sulfate 6-O-sulfotransferase 2

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NCBI Description of HS6ST2
Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HS6ST2 is highly significantly mutated in
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HS6ST2 is significantly mutated in
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HS6ST2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HS6ST2