HS6ST1 Back

heparan sulfate 6-O-sulfotransferase 1

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NCBI Description of HS6ST1
The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HS6ST1 is highly significantly mutated in
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HS6ST1 is significantly mutated in
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HS6ST1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HS6ST1