HRC Back

histidine rich calcium binding protein

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NCBI Description of HRC

This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR.

Community Annotation of HRC Add / Edit HRC: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HRC is highly significantly mutated in
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HRC is significantly mutated in
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HRC is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for HRC