HPSE2 Back

heparanase 2

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NCBI Description of HPSE2

This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.

Community Annotation of HPSE2 Add / Edit HPSE2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HPSE2 is highly significantly mutated in
HPSE2 is significantly mutated in
HPSE2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HPSE2