HPGD Back

hydroxyprostaglandin dehydrogenase 15-(NAD)

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NCBI Description of HPGD

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of HPGD Add / Edit HPGD: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HPGD is highly significantly mutated in
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HPGD is significantly mutated in
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HPGD is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for HPGD