HOXD4 Back

homeobox D4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HOXD4
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined.

Community Annotation of HOXD4 Add / Edit HOXD4: Annotations

No community annotations yet for HOXD4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HOXD4 is highly significantly mutated in
(none)
HOXD4 is significantly mutated in
(none)
HOXD4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HOXD4