HOXB4 Back

homeobox B4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HOXB4
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

Community Annotation of HOXB4 Add / Edit HOXB4: Annotations

No community annotations yet for HOXB4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HOXB4 is highly significantly mutated in
(none)
HOXB4 is significantly mutated in
(none)
HOXB4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HOXB4