HOXB3 Back

homeobox B3

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NCBI Description of HOXB3
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HOXB3 is highly significantly mutated in
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HOXB3 is significantly mutated in
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HOXB3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HOXB3