HNRPLL Back

heterogeneous nuclear ribonucleoprotein L-like

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NCBI Description of HNRPLL
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HNRPLL is highly significantly mutated in
(none)
HNRPLL is significantly mutated in
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HNRPLL is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HNRPLL