HNMT Back

histamine N-methyltransferase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HNMT
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.

Community Annotation of HNMT Add / Edit HNMT: Annotations

No community annotations yet for HNMT.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HNMT is highly significantly mutated in
(none)
HNMT is significantly mutated in
(none)
HNMT is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HNMT