HMGN3 Back

high mobility group nucleosomal binding domain 3

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NCBI Description of HMGN3

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of HMGN3 Add / Edit HMGN3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HMGN3 is highly significantly mutated in
HMGN3 is significantly mutated in
HMGN3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HMGN3