HMGB3 Back

high-mobility group box 3

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NCBI Description of HMGB3
HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997 [PubMed 9370291]; Nemeth et al., 2006 [PubMed 16945912]).[supplied by OMIM, Mar 2008].

Community Annotation of HMGB3 Add / Edit HMGB3: Annotations

No community annotations yet for HMGB3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HMGB3 is highly significantly mutated in
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HMGB3 is significantly mutated in
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HMGB3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HMGB3