HMGA1 Back

high mobility group AT-hook 1

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NCBI Description of HMGA1
This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of HMGA1 Add / Edit HMGA1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HMGA1 is highly significantly mutated in
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HMGA1 is significantly mutated in
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HMGA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HMGA1