HMCN1 Back

hemicentin 1

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NCBI Description of HMCN1
This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HMCN1 is highly significantly mutated in
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HMCN1 is significantly mutated in
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HMCN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HMCN1