helicase-like transcription factor

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NCBI Description of HLTF

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.

Community Annotation of HLTF Add / Edit HLTF: Annotations

No community annotations yet for HLTF.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


HLTF is highly significantly mutated in
HLTF is significantly mutated in
HLTF is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for HLTF