HLA-DQB1 Back

major histocompatibility complex, class II, DQ beta 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HLA-DQB1
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.

Community Annotation of HLA-DQB1 Add / Edit HLA-DQB1: Annotations

No community annotations yet for HLA-DQB1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HLA-DQB1 is highly significantly mutated in
(none)
HLA-DQB1 is significantly mutated in
(none)
HLA-DQB1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HLA-DQB1