HLA-DOA Back

major histocompatibility complex, class II, DO alpha

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NCBI Description of HLA-DOA

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HLA-DOA is highly significantly mutated in
(none)
HLA-DOA is significantly mutated in
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HLA-DOA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for HLA-DOA