HK2 Back

hexokinase 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of HK2
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Community Annotation of HK2 Add / Edit HK2: Annotations

No community annotations yet for HK2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

HK2 is highly significantly mutated in
(none)
HK2 is significantly mutated in
(none)
HK2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for HK2